Naphazoline, Phenylephrine, Menthol and Camphor Eye Drops

Trade Name :
Dews Plus

Composition :
Each ml of solution contains :
Naphazoline Hydrochloride USP 0.05% w/v + Phenylephrine Hydrochloride IP 0.12% w/v + Menthol IP 0.005% w/v + Camphor BP 0.01% w/v + Benzalkonium Chloride IP 0.01% v/v

Dosage Form :
Eye Drops

Indications :
Temporary relief of discomfort and congestion occurring with minor eye irritation due to hay fever, dust, smoke, smog, colds, wind, sun, swimming.
In allergic conjunctivitis, vernal conjunctivitis, phlyctenular conjunctivitis.
Ocular itching, redness and tearing.
Associated dry eye syndrome

CLINICAL PHARMACOLOGY

Naphazoline constricts the vascular system of the conjunctiva. It is presumed this effect is due to direct action of the drug upon the α-adrenergic receptors of the vascular smooth muscle. Its action is characterised by a long duration.

Phenylephrine causes decongestion in the eye by constricting blood vessels. It also enlarges the pupil and it reduces the amount of fluid in the eye by reducing the production and increasing the drainage.

Menthol and camphor provide cooling and soothing effect.

Dews Plus eye drops contains a unique, mild, non-sensitizing preservative that when used, ultimately changes into components of natural tears (sodium chloride and water).

Low concentration of Menthol gives prompt cooling and soothing effect while Camphor offers soothing and analgesic action.

Dosage and Administration :
The usual recommended dose of OCUREST PLUS is 1-2 drops q.i.d

Contraindications :
The use of Eye Drops is contraindicated in patients with narrow angle glaucoma

Precautions :
The use of eye drops should be with caution in patients with heart disease, hypertension or difficulty in urination due to enlargement of the prostate gland. Prolonged use of decongestants is associated with rebound congestion. The use should be discontinued If patient experiences pain, changes in vision, continued redness or irritation, or if the condition worsens, or persists for more than 72 hours. It is advisable not to drive, operate machinery or perform other hazardous activities when on treatment.

PREGNANCY & LACTATION :
There are no well-controlled trials with Dews Plus in pregnant and lactating women. Therefore, Itshould only be used if clearly indicated.

Drug Interaction :
Although, clinically significant drug-drug interactions between Dews Plus and systemically administered drugs are not expected but may occur when co-administered with monoamine oxidase inhibitors or beta blockers.

ADVERSE REACTIONS :
Prolonged use of decongestants may result in rebound congestion. Adverse reactions to with Eye Drops are rare and may include tachycardia, hypertension, headache, blurred vision and flushed skin. Pupillary dilation with increased intra-ocular pressure and drowsiness may be experienced by some patients.

Packaging :
10 ml round low density polyethylene bottle with a dispensing plug and white polypropylene screw cap containing 10 ml solution.

STORAGE :
In dry place protected from light at a temperature below 25°С. Do not freeze. After instillation the vial should be tightly closed. Keep out of reach of children.

Shelf Life :
2 years after opening the vial it is suitable for use within 1 month.
Do not use after the expiration date stated on the package