Flurbiprofen Sodium &Gatifloxacin with HPMC Ophthalmic Solution

Trade Name :
Flugati

Composition :
Flurbiprofen Sodium IP 0.03% w/v + Gatifloxacin IP eq. to Anhydrous Gatifloxacin 0.3% w/v + Hydroxymethyl Cellulose IP 0.25% w/v + Benzalkonium Chloride Solution IP 0.02% v/v

Dosage Form :
Eye Drops

Indications :
Bacterial eye infection in adults and children older than 1 year of age
Before certain types of eye surgery
Before cataract removal.

Description :
Flugati is an effective combination of 4th generation quinolone & time trusted NSAID contains Gatifloxacin has a unique mode of action which inhibits DNA gyrase and topoisomerase IV.
Flurbiprofen Sodium is one of a series of phenylalkanoic acids that have shown analgesic, antipyretic and antiinflammatory activity. It is a water soluble drug. It is a Cox-2 inhibitor and inhibits the release of prostaglandin and hence it controls the inflammation. It has a least irritation amongst all the NSAIDs, drug of choice in pre &post-operative cases to inhibit the intra-operative miosis.

Mechanism of Action :
Gatifloxacin is a synthetic broad-spectrum antibacterial agent. The bactericidal action of Gatifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Gatifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria
Flurbiprofen, a nonsteroidal anti-inflammatory agent (NSAIA) of the propionic acid class, Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhibition of cyclooxygenase (COX), the enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This effectively decreases the concentration of prostaglandins involved in inflammation

Dosage instillation :
Instil 1-2 drop to affected eye approximately every 30 minutes, beginning 2 hours before surgery (total of 4 drops) and 1 drop at an interval every 4 hours for 1 to 3 weeks after surgery.

Contraindications :
Hypersensitivity to any active ingredient or to any of the ingredients in the formula or to other NSAID.

Shelf-Life :
15 months
1 month after opening the bottle
Do not use after expiration date printed on the packaging.

Packaging Information :
5 ml round low density polyethylene bottle with a dispensing plug and white polypropylene screw cap containing 5 ml suspension

Storage and Handling Instructions :
Store at temperatures below 25 °C in a dark place
Do not freeze. Keep out of reach of children.